维贝基因？自然(ish)语言蛋白质基因组设计软件

蛋白质设计工具可能越来越精密，但是你仍然需要对蛋白质结构的精密理解才能工作。 这可以包括知道酶机理到特定氨基酸的位置，以及同样占据催化物发生地区的水分子。 一旦指定这些，这些工具可以围绕这个目标构建蛋白质的其余部分。

然而，在中国的研究人员的大力合作，决定把蛋白质设计带给大众，制作一种工具，可以采取自然语言的提示，用它们来生产蛋白质，与你指定的功能。 如果你成功的衡量标准是工作蛋白质，那么成功率可能不高。 但他们还是设法完成任务。 Hugging Face在另外的公告中表示，它现在主持一个工具

等同的感官编码可能已经出现在蛋白质设计上——至少你可以进入一个实验室，从几十个失败的实验室中排序出好的设计。

注重职能

一些最好的蛋白质设计工具通过两个步骤进行。 首先，您指定了一组约束，比如需要绑定另一个分子或者有氨基酸的特定排列。 一个AI工具然后生成一个蛋白质的形状，可以满足这些限制。 一旦完成，一个单独的工具会穿透并填充出一个形状，它具有特定的氨基酸序列，可以保证蛋白质折叠成适当的配置，以匹配形状。

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Protein design tools may be getting increasingly sophisticated, but you still need a sophisticated understanding of protein structure for them to work. This can include knowing enzyme mechanisms down to the positions of specific amino acids, as well as the water molecules that also occupy the area where catalysis takes place. Once you specify these, the tools can build the rest of a protein around this target.

A large collaboration of researchers based in China, however, decided to bring protein design to the masses, making a tool that can take natural language prompts and use them to produce proteins with the function you specify. If your measure for success is a working protein, then the success rate may not be great. But they still manage to get the job done. And, in a separate announcement, Hugging Face shared that it’s now hosting a tool that does similar things on the DNA level.

The equivalent of vibe coding may have come to protein design—at least if you have access to a lab where you can sort the good designs from the dozens of failed ones.

Focusing on function

Some of the best protein design tools we have available right now work through a two-step process. First, you specify a set of constraints, such as the need to bind another molecule or to have a specific arrangement of amino acids. One AI tool then generates the shape of a protein that can meet those constraints. Once that’s done, a separate tool goes through and populates that shape with a specific sequence of amino acids that can ensure the protein folds into the appropriate configuration to match the shape.

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